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Distinct states of proinsulin misfolding in MIDY

A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)–Cys(A20) “interchain” disulfide bond, facilitating formation of the Cys(B7)–Cys(A7) bridge. The third proinsulin di...

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Detalles Bibliográficos
Autores principales: Haataja, Leena, Arunagiri, Anoop, Hassan, Anis, Regan, Kaitlin, Tsai, Billy, Dhayalan, Balamurugan, Weiss, Michael A., Liu, Ming, Arvan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316239/
https://www.ncbi.nlm.nih.gov/pubmed/34245311
http://dx.doi.org/10.1007/s00018-021-03871-1