Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Apolipoprotein L1 (ApoL1) is a circulating innate immunity protein protecting against trypanosome infection. However, two ApoL1 coding variants are associated with a highly increased risk of chronic kidney disease. Here we present X-ray and NMR structures of the N-terminal domain (NTD) of ApoL1 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Ultsch, Mark, Holliday, Michael J., Gerhardy, Stefan, Moran, Paul, Scales, Suzie J., Gupta, Nidhi, Oltrabella, Francesca, Chiu, Cecilia, Fairbrother, Wayne, Eigenbrot, Charles, Kirchhofer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316464/
https://www.ncbi.nlm.nih.gov/pubmed/34316015
http://dx.doi.org/10.1038/s42003-021-02387-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316464/
https://www.ncbi.nlm.nih.gov/pubmed/34316015
http://dx.doi.org/10.1038/s42003-021-02387-5

Ejemplares similares