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Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target

Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that inhibits factor VIIa and Xa in the coagulation cascade. It has been shown that forkhead box P3 protein is a TFPI transcriptional repressor. However, there are no studies on chromatin remodeling that control TFPI expression. We h...

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Detalles Bibliográficos
Autores principales: Raman, Revathi, Fallatah, Weam, Al Qaryoute, Ayah, Dhinoja, Sanchi, Jagadeeswaran, Pudur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316476/
https://www.ncbi.nlm.nih.gov/pubmed/34315984
http://dx.doi.org/10.1038/s41598-021-94715-2