Gαq activation modulates autophagy by promoting mTORC1 signaling

The mTORC1 node plays a major role in autophagy modulation. We report a role of the ubiquitous Gαq subunit, a known transducer of plasma membrane G protein-coupled receptors signaling, as a core modulator of mTORC1 and autophagy. Cells lacking Gαq/11 display higher basal autophagy, enhanced autophag...

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Detalles Bibliográficos
Autores principales: Cabezudo, Sofía, Sanz-Flores, Maria, Caballero, Alvaro, Tasset, Inmaculada, Rebollo, Elena, Diaz, Antonio, Aragay, Anna M., Cuervo, Ana María, Mayor, Federico, Ribas, Catalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316552/
https://www.ncbi.nlm.nih.gov/pubmed/34315875
http://dx.doi.org/10.1038/s41467-021-24811-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316552/
https://www.ncbi.nlm.nih.gov/pubmed/34315875
http://dx.doi.org/10.1038/s41467-021-24811-4

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