The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

In the earliest step of spliceosome assembly, the two splice sites flanking an intron are brought into proximity by U1 snRNP and U2AF along with other proteins. The mechanism that facilitates this intron looping is poorly understood. Using a CRISPR interference-based approach to halt RNA polymerase...

Descripción completa

Detalles Bibliográficos
Autores principales: Leader, Yodfat, Lev Maor, Galit, Sorek, Matan, Shayevitch, Ronna, Hussein, Maram, Hameiri, Ofir, Tammer, Luna, Zonszain, Jonathan, Keydar, Ifat, Hollander, Dror, Meshorer, Eran, Ast, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316553/
https://www.ncbi.nlm.nih.gov/pubmed/34315864
http://dx.doi.org/10.1038/s41467-021-24774-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316553/
https://www.ncbi.nlm.nih.gov/pubmed/34315864
http://dx.doi.org/10.1038/s41467-021-24774-6

Ejemplares similares