Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer

The formation of amyloid fibrils from Tau is a key pathogenic feature of Alzheimer’s disease (AD). To disturb the formation of Tau aggregates is considered as a promising therapeutic strategy for AD. Recently, a natural product proanthocyanidin B2 (PB2) was confirmed to not only inhibit Tau aggregat...

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Detalles Bibliográficos
Autores principales: Li, Qin, Xiong, Chunmei, Liu, Hongli, Ge, Huizhen, Yao, Xiaojun, Liu, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316602/
https://www.ncbi.nlm.nih.gov/pubmed/34336783
http://dx.doi.org/10.3389/fchem.2021.666043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316602/
https://www.ncbi.nlm.nih.gov/pubmed/34336783
http://dx.doi.org/10.3389/fchem.2021.666043

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