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Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland

OBJECTIVES: To determine the variation in SARS-CoV-2 seroprevalence in school children and the relationship with self-reported symptoms. DESIGN: Baseline measurements of a longitudinal cohort study (Ciao Corona) from June to July 2020. SETTING: 55 schools stratified by district in the canton of Zuri...

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Autores principales: Ulyte, Agne, Radtke, Thomas, Abela, Irene Alma, Haile, Sarah R, Blankenberger, Jacob, Jung, Ruedi, Capelli, Celine, Berger, Christoph, Frei, Anja, Huber, Michael, Schanz, Merle, Schwarzmueller, Magdalena, Trkola, Alexandra, Fehr, Jan, Puhan, Milo Alan, Kriemler, Susi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316698/
https://www.ncbi.nlm.nih.gov/pubmed/34312201
http://dx.doi.org/10.1136/bmjopen-2020-047483
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author Ulyte, Agne
Radtke, Thomas
Abela, Irene Alma
Haile, Sarah R
Blankenberger, Jacob
Jung, Ruedi
Capelli, Celine
Berger, Christoph
Frei, Anja
Huber, Michael
Schanz, Merle
Schwarzmueller, Magdalena
Trkola, Alexandra
Fehr, Jan
Puhan, Milo Alan
Kriemler, Susi
author_facet Ulyte, Agne
Radtke, Thomas
Abela, Irene Alma
Haile, Sarah R
Blankenberger, Jacob
Jung, Ruedi
Capelli, Celine
Berger, Christoph
Frei, Anja
Huber, Michael
Schanz, Merle
Schwarzmueller, Magdalena
Trkola, Alexandra
Fehr, Jan
Puhan, Milo Alan
Kriemler, Susi
author_sort Ulyte, Agne
collection PubMed
description OBJECTIVES: To determine the variation in SARS-CoV-2 seroprevalence in school children and the relationship with self-reported symptoms. DESIGN: Baseline measurements of a longitudinal cohort study (Ciao Corona) from June to July 2020. SETTING: 55 schools stratified by district in the canton of Zurich, Switzerland. PARTICIPANTS: 2585 children (1339 girls; median age: 11 years, age range: 6–16 years), attending grades 1–2, 4–5 and 7–8. MAIN OUTCOME MEASURES: Variation in seroprevalence of SARS-CoV-2 in children across 12 cantonal districts, schools and grades, assessed using Luminex-based test of four epitopes for IgG, IgA and IgM (Antibody Coronavirus Assay, ABCORA 2.0). Clustering of cases within classes. Association of seropositivity and symptoms. Comparison with seroprevalence in adult population, assessed using Luminex-based test of IgG and IgA (Sensitive Anti-SARS-CoV-2 Spike Trimer Immunoglobulin Serological test). RESULTS: Overall seroprevalence was 2.8% (95% CI 1.5% to 4.1%), ranging from 1.0% to 4.5% across districts. Seroprevalence in grades 1–2 was 3.8% (95% CI 2.0% to 6.1%), in grades 4–5 was 2.4% (95% CI 1.1% to 4.2%) and in grades 7–8 was 1.5% (95% CI 0.5% to 3.0%). At least one seropositive child was present in 36 of 55 (65%) schools and in 44 (34%) of 131 classes where ≥5 children and ≥50% of children within the class were tested. 73% of children reported COVID-19-compatible symptoms since January 2020, with the same frequency in seropositive and seronegative children for all symptoms. Seroprevalence of children and adults was similar (3.2%, 95% credible interval (CrI) 1.7% to 5.0% vs 3.6%, 95% CrI 1.7% to 5.4%). The ratio of confirmed SARS-CoV-2 cumulative incidence-to-seropositive cases was 1:89 in children and 1:12 in adults. CONCLUSIONS: SARS-CoV-2 seroprevalence was low in children and similar to that in adults by the end of June 2020. Very low ratio of diagnosed-to-seropositive children was observed. We did not detect clustering of SARS-CoV-2-seropositive children within classes, but the follow-up of this study will shed more light on transmission within schools. TRIAL REGISTRATION NUMBER: NCT04448717.
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spelling pubmed-83166982021-07-30 Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland Ulyte, Agne Radtke, Thomas Abela, Irene Alma Haile, Sarah R Blankenberger, Jacob Jung, Ruedi Capelli, Celine Berger, Christoph Frei, Anja Huber, Michael Schanz, Merle Schwarzmueller, Magdalena Trkola, Alexandra Fehr, Jan Puhan, Milo Alan Kriemler, Susi BMJ Open Epidemiology OBJECTIVES: To determine the variation in SARS-CoV-2 seroprevalence in school children and the relationship with self-reported symptoms. DESIGN: Baseline measurements of a longitudinal cohort study (Ciao Corona) from June to July 2020. SETTING: 55 schools stratified by district in the canton of Zurich, Switzerland. PARTICIPANTS: 2585 children (1339 girls; median age: 11 years, age range: 6–16 years), attending grades 1–2, 4–5 and 7–8. MAIN OUTCOME MEASURES: Variation in seroprevalence of SARS-CoV-2 in children across 12 cantonal districts, schools and grades, assessed using Luminex-based test of four epitopes for IgG, IgA and IgM (Antibody Coronavirus Assay, ABCORA 2.0). Clustering of cases within classes. Association of seropositivity and symptoms. Comparison with seroprevalence in adult population, assessed using Luminex-based test of IgG and IgA (Sensitive Anti-SARS-CoV-2 Spike Trimer Immunoglobulin Serological test). RESULTS: Overall seroprevalence was 2.8% (95% CI 1.5% to 4.1%), ranging from 1.0% to 4.5% across districts. Seroprevalence in grades 1–2 was 3.8% (95% CI 2.0% to 6.1%), in grades 4–5 was 2.4% (95% CI 1.1% to 4.2%) and in grades 7–8 was 1.5% (95% CI 0.5% to 3.0%). At least one seropositive child was present in 36 of 55 (65%) schools and in 44 (34%) of 131 classes where ≥5 children and ≥50% of children within the class were tested. 73% of children reported COVID-19-compatible symptoms since January 2020, with the same frequency in seropositive and seronegative children for all symptoms. Seroprevalence of children and adults was similar (3.2%, 95% credible interval (CrI) 1.7% to 5.0% vs 3.6%, 95% CrI 1.7% to 5.4%). The ratio of confirmed SARS-CoV-2 cumulative incidence-to-seropositive cases was 1:89 in children and 1:12 in adults. CONCLUSIONS: SARS-CoV-2 seroprevalence was low in children and similar to that in adults by the end of June 2020. Very low ratio of diagnosed-to-seropositive children was observed. We did not detect clustering of SARS-CoV-2-seropositive children within classes, but the follow-up of this study will shed more light on transmission within schools. TRIAL REGISTRATION NUMBER: NCT04448717. BMJ Publishing Group 2021-07-26 /pmc/articles/PMC8316698/ /pubmed/34312201 http://dx.doi.org/10.1136/bmjopen-2020-047483 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Epidemiology
Ulyte, Agne
Radtke, Thomas
Abela, Irene Alma
Haile, Sarah R
Blankenberger, Jacob
Jung, Ruedi
Capelli, Celine
Berger, Christoph
Frei, Anja
Huber, Michael
Schanz, Merle
Schwarzmueller, Magdalena
Trkola, Alexandra
Fehr, Jan
Puhan, Milo Alan
Kriemler, Susi
Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title_full Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title_fullStr Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title_full_unstemmed Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title_short Variation in SARS-CoV-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in Switzerland
title_sort variation in sars-cov-2 seroprevalence across districts, schools and classes: baseline measurements from a cohort of primary and secondary school children in switzerland
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316698/
https://www.ncbi.nlm.nih.gov/pubmed/34312201
http://dx.doi.org/10.1136/bmjopen-2020-047483
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