Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction

[Image: see text] Although it is well-known that limited local mutations of enzymes, such as matrix metalloproteinases (MMPs), may change enzyme activity by orders of magnitude as well as its stability, the completely rational design of proteins is still challenging. These local changes alter the el...

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Detalles Bibliográficos
Autores principales: Adams, Ellen M., Pezzotti, Simone, Ahlers, Jonas, Rüttermann, Maximilian, Levin, Maxim, Goldenzweig, Adi, Peleg, Yoav, Fleishman, Sarel J., Sagi, Irit, Havenith, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317155/
https://www.ncbi.nlm.nih.gov/pubmed/34337607
http://dx.doi.org/10.1021/jacsau.1c00155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317155/
https://www.ncbi.nlm.nih.gov/pubmed/34337607
http://dx.doi.org/10.1021/jacsau.1c00155

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