PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys

Mutations of PTEN-induced kinase I (PINK1) cause early-onset Parkinson’s disease (PD) with selective neurodegeneration in humans. However, current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed in PD patients. This suggests that gener...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zhen-Zhen, Wang, Jian-Ying, Kang, Yu, Yang, Qiao-Yan, Gu, Xue-Ying, Zhi, Da-Long, Yan, Li, Long, Cheng-Zu, Shen, Bin, Niu, Yu-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317192/
https://www.ncbi.nlm.nih.gov/pubmed/34213093
http://dx.doi.org/10.24272/j.issn.2095-8137.2021.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317192/
https://www.ncbi.nlm.nih.gov/pubmed/34213093
http://dx.doi.org/10.24272/j.issn.2095-8137.2021.023

Ejemplares similares