Biocatalytic enantioselective hydroaminations enabling synthesis of N-arylalkyl-substituted l-aspartic acids

N-Substituted l-aspartic acids are important chiral building blocks for pharmaceuticals and food additives. Here we report the asymmetric synthesis of various N-arylalkyl-substituted l-aspartic acids using ethylenediamine-N,N′-disuccinic acid lyase (EDDS lyase) as a biocatalyst. This C–N lyase shows...

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Detalles Bibliográficos
Autores principales: Abidin, Mohammad Z., Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317194/
https://www.ncbi.nlm.nih.gov/pubmed/34235532
http://dx.doi.org/10.1039/d1ob00748c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317194/
https://www.ncbi.nlm.nih.gov/pubmed/34235532
http://dx.doi.org/10.1039/d1ob00748c

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