Combining flavin photocatalysis with parallel synthesis: a general platform to optimize peptides with non-proteinogenic amino acids

Most peptide drugs contain non-proteinogenic amino acids (NPAAs), born out through extensive structure–activity relationship (SAR) studies using solid-phase peptide synthesis (SPPS). Synthetically laborious and expensive to manufacture, NPAAs also can have poor coupling efficiencies allowing only a...

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Detalles Bibliográficos
Autores principales: Immel, Jacob R., Chilamari, Maheshwerreddy, Bloom, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317666/
https://www.ncbi.nlm.nih.gov/pubmed/34377401
http://dx.doi.org/10.1039/d1sc02562g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317666/
https://www.ncbi.nlm.nih.gov/pubmed/34377401
http://dx.doi.org/10.1039/d1sc02562g

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