Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...

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Detalles Bibliográficos
Autores principales: Evangelista, Tereza Cristina Santos, López, Óscar, Ferreira, Sabrina Baptista, Fernández-Bolaños, José G., Sydnes, Magne O., Lindbäck, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317962/
https://www.ncbi.nlm.nih.gov/pubmed/34294013
http://dx.doi.org/10.1080/14756366.2021.1954917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317962/
https://www.ncbi.nlm.nih.gov/pubmed/34294013
http://dx.doi.org/10.1080/14756366.2021.1954917

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