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Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described. The multivalent inhibition potencies for the tacrine clusters were investigated for the inhibition of acetylcholinesterase. Two of the tacrine...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8317962/ https://www.ncbi.nlm.nih.gov/pubmed/34294013 http://dx.doi.org/10.1080/14756366.2021.1954917 |