Structural basis of the effect of activating mutations on the EGF receptor

Mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are common oncogenic driver events in non-small cell lung cancer. Although the activation of EGFR in normal cells is primarily driven by growth-factor-binding-induced dimerization, mutations on different exons of the k...

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Detalles Bibliográficos
Autores principales: Galdadas, Ioannis, Carlino, Luca, Ward, Richard A, Hughes, Samantha J, Haider, Shozeb, Gervasio, Francesco Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318590/
https://www.ncbi.nlm.nih.gov/pubmed/34319231
http://dx.doi.org/10.7554/eLife.65824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318590/
https://www.ncbi.nlm.nih.gov/pubmed/34319231
http://dx.doi.org/10.7554/eLife.65824

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