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Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains
The p75 neurotrophin receptor (p75(NTR)) is a critical mediator of neuronal death and tissue remodeling and has been implicated in various neurodegenerative diseases and cancers. The death domain (DD) of p75(NTR) is an intracellular signaling hub and has been shown to interact with diverse adaptor p...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318917/ https://www.ncbi.nlm.nih.gov/pubmed/34175311 http://dx.doi.org/10.1016/j.jbc.2021.100916 |