BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

The transcription factors NFAT and AP-1 (Fos-Jun) cooperate to promote the effector functions of T cells, but NFAT in the absence of AP-1 imposes a negative feedback program of T cell hyporesponsiveness (“exhaustion”). Here we show that BATF and IRF4 cooperate to counter T cell exhaustion in mouse t...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Hyungseok, González-Avalos, Edahí, Zhang, Wade, Ramchandani, Payal, Yang, Chao, Lio, Chan-Wang J, Rao, Anjana, Hogan, Patrick G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319109/
https://www.ncbi.nlm.nih.gov/pubmed/34282330
http://dx.doi.org/10.1038/s41590-021-00964-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319109/
https://www.ncbi.nlm.nih.gov/pubmed/34282330
http://dx.doi.org/10.1038/s41590-021-00964-8

Ejemplares similares