Sphingosine-1-phosphate modulates PAR1-mediated human platelet activation in a concentration-dependent biphasic manner

Sphingosine 1-phosphate (S1P) is a bioactive signalling sphingolipid that is increased in diseases such as obesity and diabetes. S1P can modulate platelet function, however the direction of effect and S1P receptors (S1PRs) involved are controversial. Here we describe the role of S1P in regulating hu...

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Detalles Bibliográficos
Autores principales: Liu, Haonan, Jackson, Molly L., Goudswaard, Lucy J., Moore, Samantha F., Hutchinson, James L., Hers, Ingeborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319165/
https://www.ncbi.nlm.nih.gov/pubmed/34321503
http://dx.doi.org/10.1038/s41598-021-94052-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319165/
https://www.ncbi.nlm.nih.gov/pubmed/34321503
http://dx.doi.org/10.1038/s41598-021-94052-4

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