Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors

Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell lysates to show that TRAK2 robustly activates...

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Detalles Bibliográficos
Autores principales: Fenton, Adam R., Jongens, Thomas A., Holzbaur, Erika L. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319186/
https://www.ncbi.nlm.nih.gov/pubmed/34321481
http://dx.doi.org/10.1038/s41467-021-24862-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319186/
https://www.ncbi.nlm.nih.gov/pubmed/34321481
http://dx.doi.org/10.1038/s41467-021-24862-7

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