A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment

Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines. We have previously shown that BLS has a therapeutic effect in B16 melanoma-bearing mice only when administered at...

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Detalles Bibliográficos
Autores principales: Farias, A., Soto, A., Puttur, F., Goldin, C. J., Sosa, S., Gil, C., Goldbaum, F. A., Berguer, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319313/
https://www.ncbi.nlm.nih.gov/pubmed/34321536
http://dx.doi.org/10.1038/s41598-021-94837-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319313/
https://www.ncbi.nlm.nih.gov/pubmed/34321536
http://dx.doi.org/10.1038/s41598-021-94837-7

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