Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins

Covalent attachment of C16:0 to proteins (palmitoylation) regulates protein function. Proteins are also S-acylated by other fatty acids including C18:0. Whether protein acylation with different fatty acids has different functional outcomes is not well studied. We show here that C18:0 (stearate) and...

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Detalles Bibliográficos
Autores principales: Nůsková, Hana, Serebryakova, Marina V., Ferrer-Caelles, Anna, Sachsenheimer, Timo, Lüchtenborg, Christian, Miller, Aubry K., Brügger, Britta, Kordyukova, Larisa V., Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319428/
https://www.ncbi.nlm.nih.gov/pubmed/34321466
http://dx.doi.org/10.1038/s41467-021-24844-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319428/
https://www.ncbi.nlm.nih.gov/pubmed/34321466
http://dx.doi.org/10.1038/s41467-021-24844-9

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