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Loss of vacuolar-type H(+)-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts

The vacuolar-type H(+)-ATPase (V-ATPase) is a multi-subunit proton pump that regulates cellular pH. V-ATPase activity modulates several cellular processes, but cell-type-specific functions remain poorly understood. Patients with mutations in specific V-ATPase subunits can develop sensorineural deafn...

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Detalles Bibliográficos
Autores principales: Santra, Peu, Amack, Jeffrey D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319552/
https://www.ncbi.nlm.nih.gov/pubmed/34296747
http://dx.doi.org/10.1242/dmm.048997