Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m(6)A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in diabetic kidney disease (DKD). However, the mechanisms underlying the therapeutic action of this compound have yet to be eluc...

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Detalles Bibliográficos
Autores principales: Liu, Bu-Hui, Tu, Yue, Ni, Guang-Xia, Yan, Jin, Yue, Liang, Li, Zi-Lin, Wu, Jing-Jing, Cao, Yu-Ting, Wan, Zi-Yue, Sun, Wei, Wan, Yi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319635/
https://www.ncbi.nlm.nih.gov/pubmed/34335245
http://dx.doi.org/10.3389/fphar.2021.667644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319635/
https://www.ncbi.nlm.nih.gov/pubmed/34335245
http://dx.doi.org/10.3389/fphar.2021.667644

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