Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage

The persistence of leukemia stem cells (LSCs) is one of the leading causes of chemoresistance in acute myeloid leukemia (AML). To explore the factors important in LSC-mediated resistance, we use mass spectrometry to screen the factors related to LSC chemoresistance and defined IFN-γ-inducible lysoso...

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Detalles Bibliográficos
Autores principales: Niu, Li-Ting, Wang, Yu-Qing, Wong, Catherine C.L., Gao, Shuai-Xin, Mo, Xiao-Dong, Huang, Xiao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319687/
https://www.ncbi.nlm.nih.gov/pubmed/34252711
http://dx.doi.org/10.1016/j.tranon.2021.101159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8319687/
https://www.ncbi.nlm.nih.gov/pubmed/34252711
http://dx.doi.org/10.1016/j.tranon.2021.101159

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