Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy

BACKGROUND: Homocitrullination is the post-translational modification of lysine that is recognized by T cells. METHODS: This study identified homocitrullinated peptides from aldolase, enolase, cytokeratin and binding immunoglobulin protein and used human leukocyte antigen (HLA) transgenic mice to as...

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Detalles Bibliográficos
Autores principales: Cook, Katherine W, Xue, Wei, Symonds, Peter, Daniels, Ian, Gijon, Mohamed, Boocock, David, Coveney, Clare, Miles, Amanda K, Shah, Sabaria, Atabani, Suha, Choudhury, Ruhul H, Vaghela, Poonam, Weston, Daisy, Metheringham, Rachael L, Brentville, Victoria A, Durrant, Lindy G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320257/
https://www.ncbi.nlm.nih.gov/pubmed/34321274
http://dx.doi.org/10.1136/jitc-2020-001910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320257/
https://www.ncbi.nlm.nih.gov/pubmed/34321274
http://dx.doi.org/10.1136/jitc-2020-001910

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