Paclitaxel increases axonal localization and vesicular trafficking of Na(v)1.7

The microtubule-stabilizing chemotherapy drug paclitaxel (PTX) causes dose-limiting chemotherapy-induced peripheral neuropathy (CIPN), which is often accompanied by pain. Among the multifaceted effects of PTX is an increased expression of sodium channel Na(v)1.7 in rat and human sensory neurons, enh...

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Detalles Bibliográficos
Autores principales: Akin, Elizabeth J, Alsaloum, Matthew, Higerd, Grant P, Liu, Shujun, Zhao, Peng, Dib-Hajj, Fadia B, Waxman, Stephen G, Dib-Hajj, Sulayman D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320304/
https://www.ncbi.nlm.nih.gov/pubmed/33734317
http://dx.doi.org/10.1093/brain/awab113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320304/
https://www.ncbi.nlm.nih.gov/pubmed/33734317
http://dx.doi.org/10.1093/brain/awab113

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