Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine and/or losartan

OBJECTIVE: To evaluate drug-drug interactions (DDIs) between gefitinib or erlotinib with fluoxetine, and/or losartan. METHODS: Human pooled microsomes, supersomes, and cryopreserved human hepatocytes were used to monitor DDIs in vitro. RED (Rapid Equilibrium Dialysis) protein binding was employed to...

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Detalles Bibliográficos
Autores principales: Luong, Thu-Lan T., McAnulty, Michael J., Evers, David L., Reinhardt, Brian J., Weina, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320603/
https://www.ncbi.nlm.nih.gov/pubmed/34345864
http://dx.doi.org/10.1016/j.crtox.2021.05.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320603/
https://www.ncbi.nlm.nih.gov/pubmed/34345864
http://dx.doi.org/10.1016/j.crtox.2021.05.006

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