The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response. We currently report that a single 400 mg/kg acetaminophen (APAP) dose to C57BL/6J mice led to an increase in multidrug resistance-assoc...

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Detalles Bibliográficos
Autores principales: Scialis, Renato J., Ghanem, Carolina I., Manautou, José E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320619/
https://www.ncbi.nlm.nih.gov/pubmed/34345835
http://dx.doi.org/10.1016/j.crtox.2020.04.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320619/
https://www.ncbi.nlm.nih.gov/pubmed/34345835
http://dx.doi.org/10.1016/j.crtox.2020.04.002

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