RNA diversification by a self-reproducing ribozyme revealed by deep sequencing and kinetic modelling

We demonstrate that a recombinase ribozyme achieves multiple functions in the same reaction network: self-reproduction, iterative elongation and circularization of other RNAs, leading to synthesis of diverse products predicted by a kinetic model. This shows that key mechanisms can be integrated and...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeancolas, Cyrille, Matsubara, Yoshiya J., Vybornyi, Mykhailo, Lambert, Camille N., Blokhuis, Alex, Alline, Thomas, Griffiths, Andrew D., Ameta, Sandeep, Krishna, Sandeep, Nghe, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320737/
https://www.ncbi.nlm.nih.gov/pubmed/34235521
http://dx.doi.org/10.1039/d1cc02290c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320737/
https://www.ncbi.nlm.nih.gov/pubmed/34235521
http://dx.doi.org/10.1039/d1cc02290c

Ejemplares similares