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Increase of CD4(+)CD25(high)FoxP3(+) cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis
BACKGROUND: Regulatory T cells (Tregs) play a critical role during Mycobacterium tuberculosis (Mtb) infection, modulating host responses while neutralizing excessive inflammation. However, their impact on regulating host protective immunity is not completely understood. Here, we demonstrate that Tre...
Autores principales: | Stringari, Lorenzzo Lyrio, Covre, Luciana Polaco, da Silva, Flávia Dias Coelho, de Oliveira, Vivian Leite, Campana, Maria Carolina, Hadad, David Jamil, Palaci, Moisés, Salgame, Padmini, Dietze, Reynaldo, Gomes, Daniel Cláudio de Oliveira, Ribeiro-Rodrigues, Rodrigo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321116/ https://www.ncbi.nlm.nih.gov/pubmed/34324509 http://dx.doi.org/10.1371/journal.pntd.0009605 |
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