Multi-scale simulations of the T cell receptor reveal its lipid interactions, dynamics and the arrangement of its cytoplasmic region

The T cell receptor (TCR-CD3) initiates T cell activation by binding to peptides of Major Histocompatibility Complexes (pMHC). The TCR-CD3 topology is well understood but the arrangement and dynamics of its cytoplasmic tails remains unknown, limiting our grasp of the signalling mechanism. Here, we u...

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Detalles Bibliográficos
Autores principales: Prakaash, Dheeraj, Cook, Graham P., Acuto, Oreste, Kalli, Antreas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321403/
https://www.ncbi.nlm.nih.gov/pubmed/34280187
http://dx.doi.org/10.1371/journal.pcbi.1009232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321403/
https://www.ncbi.nlm.nih.gov/pubmed/34280187
http://dx.doi.org/10.1371/journal.pcbi.1009232

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