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From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology
Oligomers of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer’s disease (AD) through their toxicity towards neurons. Understanding the process of oligomerization may contribute to the development of therapeutic agents, but this has been difficult due to the complexity...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321409/ https://www.ncbi.nlm.nih.gov/pubmed/34280181 http://dx.doi.org/10.1371/journal.pcbi.1009114 |
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author | Lindstrom, Michael R. Chavez, Manuel B. Gross-Sable, Elijah A. Hayden, Eric Y. Teplow, David B. |
author_facet | Lindstrom, Michael R. Chavez, Manuel B. Gross-Sable, Elijah A. Hayden, Eric Y. Teplow, David B. |
author_sort | Lindstrom, Michael R. |
collection | PubMed |
description | Oligomers of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer’s disease (AD) through their toxicity towards neurons. Understanding the process of oligomerization may contribute to the development of therapeutic agents, but this has been difficult due to the complexity of oligomerization and the metastability of the oligomers thus formed. To understand the kinetics of oligomer formation, and how that relates to the progression of AD, we developed models of the oligomerization process. Here, we use experimental data from cell viability assays and proxies for rate constants involved in monomer-dimer-trimer kinetics to develop a simple mathematical model linking Aβ assembly to oligomer-induced neuronal degeneration. This model recapitulates the rapid growth of disease incidence with age. It does so through incorporation of age-dependent changes in rates of Aβ monomer production and elimination. The model also describes clinical progression in genetic forms of AD (e.g., Down’s syndrome), changes in hippocampal volume, AD risk after traumatic brain injury, and spatial spreading of the disease due to foci in which Aβ production is elevated. Continued incorporation of clinical and basic science data into the current model will make it an increasingly relevant model system for doing theoretical calculations that are not feasible in biological systems. In addition, terms in the model that have particularly large effects are likely to be especially useful therapeutic targets. |
format | Online Article Text |
id | pubmed-8321409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83214092021-07-31 From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology Lindstrom, Michael R. Chavez, Manuel B. Gross-Sable, Elijah A. Hayden, Eric Y. Teplow, David B. PLoS Comput Biol Research Article Oligomers of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer’s disease (AD) through their toxicity towards neurons. Understanding the process of oligomerization may contribute to the development of therapeutic agents, but this has been difficult due to the complexity of oligomerization and the metastability of the oligomers thus formed. To understand the kinetics of oligomer formation, and how that relates to the progression of AD, we developed models of the oligomerization process. Here, we use experimental data from cell viability assays and proxies for rate constants involved in monomer-dimer-trimer kinetics to develop a simple mathematical model linking Aβ assembly to oligomer-induced neuronal degeneration. This model recapitulates the rapid growth of disease incidence with age. It does so through incorporation of age-dependent changes in rates of Aβ monomer production and elimination. The model also describes clinical progression in genetic forms of AD (e.g., Down’s syndrome), changes in hippocampal volume, AD risk after traumatic brain injury, and spatial spreading of the disease due to foci in which Aβ production is elevated. Continued incorporation of clinical and basic science data into the current model will make it an increasingly relevant model system for doing theoretical calculations that are not feasible in biological systems. In addition, terms in the model that have particularly large effects are likely to be especially useful therapeutic targets. Public Library of Science 2021-07-19 /pmc/articles/PMC8321409/ /pubmed/34280181 http://dx.doi.org/10.1371/journal.pcbi.1009114 Text en © 2021 Lindstrom et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lindstrom, Michael R. Chavez, Manuel B. Gross-Sable, Elijah A. Hayden, Eric Y. Teplow, David B. From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title | From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title_full | From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title_fullStr | From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title_full_unstemmed | From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title_short | From reaction kinetics to dementia: A simple dimer model of Alzheimer’s disease etiology |
title_sort | from reaction kinetics to dementia: a simple dimer model of alzheimer’s disease etiology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321409/ https://www.ncbi.nlm.nih.gov/pubmed/34280181 http://dx.doi.org/10.1371/journal.pcbi.1009114 |
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