Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy

αvβ8 integrin, a key activator of transforming growth factor β (TGF-β), inhibits anti-tumor immunity. We show that a potent blocking monoclonal antibody against αvβ8 (ADWA-11) causes growth suppression or complete regression in syngeneic models of squamous cell carcinoma, mammary cancer, colon cance...

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Detalles Bibliográficos
Autores principales: Dodagatta-Marri, Eswari, Ma, Hsiao-Yen, Liang, Benjia, Li, John, Meyer, Dominique S., Chen, Szu-Ying, Sun, Kai-Hui, Ren, Xin, Zivak, Bahar, Rosenblum, Michael D., Headley, Mark B., Pinzas, Lauren, Reed, Nilgun I., Del Cid, Joselyn S., Hann, Byron C., Yang, Sharon, Giddabasappa, Anand, Noorbehesht, Kavon, Yang, Bing, Porto, Joseph Dal, Tsukui, Tatsuya, Niessen, Kyle, Atakilit, Amha, Akhurst, Rosemary J., Sheppard, Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321414/
https://www.ncbi.nlm.nih.gov/pubmed/34233193
http://dx.doi.org/10.1016/j.celrep.2021.109309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321414/
https://www.ncbi.nlm.nih.gov/pubmed/34233193
http://dx.doi.org/10.1016/j.celrep.2021.109309

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