CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

A growing number of human diseases have been found to be associated with aberrant DNA methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2) that produce TET inhibitory metabolite, 2-hy...

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Detalles Bibliográficos
Autores principales: Liu, Peng, Liu, Jin-Pin, Sun, Si-Jia, Gao, Yun, Ai, Yingjie, Chen, Xiufei, Sun, Yiping, Zhou, Mengyu, Liu, Yun, Xiong, Yue, Yuan, Hai-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321512/
https://www.ncbi.nlm.nih.gov/pubmed/34336831
http://dx.doi.org/10.3389/fcell.2021.675424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321512/
https://www.ncbi.nlm.nih.gov/pubmed/34336831
http://dx.doi.org/10.3389/fcell.2021.675424

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