Kinetic Analysis Suggests Evolution of Ribosome Specificity in Modern Elongation Factor-Tus from “Generalist” Ancestors

It has been hypothesized that early enzymes are more promiscuous than their extant orthologs. Whether or not this hypothesis applies to the translation machinery, the oldest molecular machine of life, is not known. Efficient protein synthesis relies on a cascade of specific interactions between the...

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Detalles Bibliográficos
Autores principales: De Tarafder, Arindam, Parajuli, Narayan Prasad, Majumdar, Soneya, Kaçar, Betül, Sanyal, Suparna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321524/
https://www.ncbi.nlm.nih.gov/pubmed/33871630
http://dx.doi.org/10.1093/molbev/msab114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321524/
https://www.ncbi.nlm.nih.gov/pubmed/33871630
http://dx.doi.org/10.1093/molbev/msab114

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