Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

Aggregation and accumulation of amyloid-β (Aβ) is a defining feature of Alzheimer’s disease pathology. To study microglial responses to Aβ, we applied exogenous Aβ peptide, in either oligomeric or fibrillar conformation, to primary mouse microglial cultures and evaluated system-level transcriptional...

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Detalles Bibliográficos
Autores principales: McFarland, Karen N, Ceballos, Carolina, Rosario, Awilda, Ladd, Thomas, Moore, Brenda, Golde, Griffin, Wang, Xue, Allen, Mariet, Ertekin-Taner, Nilüfer, Funk, Cory C, Robinson, Max, Baloni, Priyanka, Rappaport, Noa, Chakrabarty, Paramita, Golde, Todd E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321667/
https://www.ncbi.nlm.nih.gov/pubmed/34127518
http://dx.doi.org/10.26508/lsa.202101108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321667/
https://www.ncbi.nlm.nih.gov/pubmed/34127518
http://dx.doi.org/10.26508/lsa.202101108

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