The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair

DNA polymerase δ, which contains the catalytic subunit, Pol3, Pol31, and Pol32, contributes both to DNA replication and repair. The deletion of pol31 is lethal, and compromising the Pol3–Pol31 interaction domains confers hypersensitivity to cold, hydroxyurea (HU), and methyl methanesulfonate, phenoc...

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Detalles Bibliográficos
Autores principales: Shimada, Kenji, Tsai-Pflugfelder, Monika, Vijeh Motlagh, Niloofar Davoodi, Delgoshaie, Neda, Fuchs, Jeannette, Gut, Heinz, Gasser, Susan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321694/
https://www.ncbi.nlm.nih.gov/pubmed/34226278
http://dx.doi.org/10.26508/lsa.202101138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321694/
https://www.ncbi.nlm.nih.gov/pubmed/34226278
http://dx.doi.org/10.26508/lsa.202101138

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