JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules

SARS-CoV-2 infections initiate cytokine storms and activate genetic programs leading to progressive hyperinflammation in multiple organs of patients with COVID-19. While it is known that COVID-19 impacts kidney function, leading to increased mortality, cytokine response of renal epithelium has not b...

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Detalles Bibliográficos
Autores principales: Jankowski, Jakub, Lee, Hye Kyung, Wilflingseder, Julia, Hennighausen, Lothar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321697/
https://www.ncbi.nlm.nih.gov/pubmed/34345808
http://dx.doi.org/10.1016/j.isci.2021.102928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321697/
https://www.ncbi.nlm.nih.gov/pubmed/34345808
http://dx.doi.org/10.1016/j.isci.2021.102928

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