Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations to thick and thinfilament proteins. Although thin filament mutations are less prevalent than their oft-studied thick filament counterparts, they are frequently associated with severe patient phenotypes and can o...

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Detalles Bibliográficos
Autores principales: Sewanan, Lorenzo R., Park, Jinkyu, Rynkiewicz, Michael J., Racca, Alice W., Papoutsidakis, Nikolaos, Schwan, Jonas, Jacoby, Daniel L., Moore, Jeffrey R., Lehman, William, Qyang, Yibing, Campbell, Stuart G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321830/
https://www.ncbi.nlm.nih.gov/pubmed/34319370
http://dx.doi.org/10.1085/jgp.202012640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321830/
https://www.ncbi.nlm.nih.gov/pubmed/34319370
http://dx.doi.org/10.1085/jgp.202012640

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