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Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation
Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations to thick and thinfilament proteins. Although thin filament mutations are less prevalent than their oft-studied thick filament counterparts, they are frequently associated with severe patient phenotypes and can o...
Autores principales: | Sewanan, Lorenzo R., Park, Jinkyu, Rynkiewicz, Michael J., Racca, Alice W., Papoutsidakis, Nikolaos, Schwan, Jonas, Jacoby, Daniel L., Moore, Jeffrey R., Lehman, William, Qyang, Yibing, Campbell, Stuart G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321830/ https://www.ncbi.nlm.nih.gov/pubmed/34319370 http://dx.doi.org/10.1085/jgp.202012640 |
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