Hyaluronidase expression within tumors increases virotherapy efficacy and T cell accumulation

Oncolytic viruses (OVs) preferentially infect and selectively replicate in cancer cells. OVs have been tested in clinical trials as monotherapy or in combination with chemotherapy, radiotherapy, and immunotherapy. However, the dense extracellular matrix hampers the intratumoral spreading and efficac...

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Detalles Bibliográficos
Autores principales: Farrera-Sal, Martí, Moreno, Rafael, Mato-Berciano, Ana, Maliandi, María Victoria, Bazan-Peregrino, Miriam, Alemany, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321894/
https://www.ncbi.nlm.nih.gov/pubmed/34377767
http://dx.doi.org/10.1016/j.omto.2021.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321894/
https://www.ncbi.nlm.nih.gov/pubmed/34377767
http://dx.doi.org/10.1016/j.omto.2021.05.009

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