A novel homeostatic loop of sorcin drives paclitaxel-resistance and malignant progression via Smad4/ZEB1/miR-142-5p in human ovarian cancer

The primary chemotherapy of ovarian cancer (OC) often acquires chemoresistance. Sorcin (SRI), a soluble resistance-related calcium-binding protein, has been reported to be an oncogenic protein in cancer. However, the molecular mechanisms of SRI regulation and the role and aberrant expression of SRI...

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Detalles Bibliográficos
Autores principales: Zhang, Jinguo, Guan, Wencai, Xu, Xiaolin, Wang, Fanchen, Li, Xin, Xu, Guoxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321900/
https://www.ncbi.nlm.nih.gov/pubmed/34163033
http://dx.doi.org/10.1038/s41388-021-01891-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321900/
https://www.ncbi.nlm.nih.gov/pubmed/34163033
http://dx.doi.org/10.1038/s41388-021-01891-6

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