APOBEC3-induced mutation of the hepatitis virus B DNA genome occurs during its viral RNA reverse transcription into (−)-DNA

APOBEC3s are innate single-stranded DNA cytidine-to-uridine deaminases that catalyze mutations in both pathogen and human genomes with significant roles in human disease. However, how APOBEC3s mutate a single-stranded DNA that is available momentarily during DNA transcription or replication in vivo...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Zhigang, Eggerman, Thomas L., Bocharov, Alexander V., Baranova, Irina N., Vishnyakova, Tatyana G., Patterson, Amy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321922/
https://www.ncbi.nlm.nih.gov/pubmed/34181944
http://dx.doi.org/10.1016/j.jbc.2021.100889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8321922/
https://www.ncbi.nlm.nih.gov/pubmed/34181944
http://dx.doi.org/10.1016/j.jbc.2021.100889

Ejemplares similares