Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL(pro): Inhibition potentials, covalent binding sites and inhibitory mechanisms

Coronavirus 3C-like protease (3CL(pro)) is a crucial target for treating coronavirus diseases including COVID-19. Our preliminary screening showed that Ampelopsis grossedentata extract (AGE) displayed potent SARS-CoV-2-3CL(pro) inhibitory activity, but the key constituents with SARS-CoV-2-3CL(pro) i...

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Detalles Bibliográficos
Autores principales: Xiong, Yuan, Zhu, Guang-Hao, Zhang, Ya-Ni, Hu, Qing, Wang, Hao-Nan, Yu, Hao-Nan, Qin, Xiao-Ya, Guan, Xiao-Qing, Xiang, Yan-Wei, Tang, Hui, Ge, Guang-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322037/
https://www.ncbi.nlm.nih.gov/pubmed/34333006
http://dx.doi.org/10.1016/j.ijbiomac.2021.07.167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322037/
https://www.ncbi.nlm.nih.gov/pubmed/34333006
http://dx.doi.org/10.1016/j.ijbiomac.2021.07.167

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