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Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL(pro): Inhibition potentials, covalent binding sites and inhibitory mechanisms

Coronavirus 3C-like protease (3CL(pro)) is a crucial target for treating coronavirus diseases including COVID-19. Our preliminary screening showed that Ampelopsis grossedentata extract (AGE) displayed potent SARS-CoV-2-3CL(pro) inhibitory activity, but the key constituents with SARS-CoV-2-3CL(pro) i...

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Detalles Bibliográficos
Autores principales:	Xiong, Yuan, Zhu, Guang-Hao, Zhang, Ya-Ni, Hu, Qing, Wang, Hao-Nan, Yu, Hao-Nan, Qin, Xiao-Ya, Guan, Xiao-Qing, Xiang, Yan-Wei, Tang, Hui, Ge, Guang-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Published by Elsevier B.V. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322037/ https://www.ncbi.nlm.nih.gov/pubmed/34333006 http://dx.doi.org/10.1016/j.ijbiomac.2021.07.167

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