A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer’s disease and tauopathy in mice

Accumulation of tau protein is a key pathology of age-related neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy. Those diseases are collectively termed tauopathies. Tau pathology is associated with axonal degeneration because tau binds to microtubules (MT...

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Detalles Bibliográficos
Autores principales: Onishi, Tomohiro, Maeda, Ryouta, Terada, Michiko, Sato, Sho, Fujii, Takahiro, Ito, Masahiro, Hashikami, Kentaro, Kawamoto, Tomohiro, Tanaka, Maiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322070/
https://www.ncbi.nlm.nih.gov/pubmed/34326423
http://dx.doi.org/10.1038/s41598-021-94923-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322070/
https://www.ncbi.nlm.nih.gov/pubmed/34326423
http://dx.doi.org/10.1038/s41598-021-94923-w

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