Assessment of genetic changes and neurovirulence of shed Sabin and novel type 2 oral polio vaccine viruses

Sabin-strain oral polio vaccines (OPV) can, in rare instances, cause disease in recipients and susceptible contacts or evolve to become circulating vaccine-derived strains with the potential to cause outbreaks. Two novel type 2 OPV (nOPV2) candidates were designed to stabilize the genome against the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wahid, Rahnuma, Mercer, Laina, Macadam, Andrew, Carlyle, Sarah, Stephens, Laura, Martin, Javier, Chumakov, Konstantin, Laassri, Majid, Petrovskaya, Svetlana, Smits, Saskia L., Stittelaar, Koert J., Gast, Chris, Weldon, William C., Konopka-Anstadt, Jennifer L., Steven Oberste, M., Van Damme, Pierre, De Coster, Ilse, Rüttimann, Ricardo, Bandyopadhyay, Ananda, Konz, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322168/
https://www.ncbi.nlm.nih.gov/pubmed/34326330
http://dx.doi.org/10.1038/s41541-021-00355-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322168/
https://www.ncbi.nlm.nih.gov/pubmed/34326330
http://dx.doi.org/10.1038/s41541-021-00355-y

Ejemplares similares