Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs

Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in development. For example, long QT syndrome‐3 (LQTS3) is caus...

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Detalles Bibliográficos
Autores principales: Gomez‐Galeno, Jorge, Okolotowicz, Karl, Johnson, Mark, McKeithan, Wesley L., Mercola, Mark, Cashman, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322572/
https://www.ncbi.nlm.nih.gov/pubmed/34327875
http://dx.doi.org/10.1002/prp2.828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322572/
https://www.ncbi.nlm.nih.gov/pubmed/34327875
http://dx.doi.org/10.1002/prp2.828

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