Slug promotes p53 and p21 protein degradation by inducing Mdm2 expression in HCT116 colon cancer cells

Our previous study revealed that the tumor suppressor/transcription factor p53 directly binds to its transcriptional target, p21, and that the p53/p21 complex binds to zinc finger protein SNAI2 (Slug), a tumor promoter/transcription factor; thereby promoting the degradation of Slug by Mdm2, an E3 li...

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Detalles Bibliográficos
Autores principales: Kim, Jongdoo, Lee, Jihyun, Kim, Ukjin, Park, Jong-Kuk, Um, Hong-Duck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323001/
https://www.ncbi.nlm.nih.gov/pubmed/34345306
http://dx.doi.org/10.3892/ol.2021.12942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323001/
https://www.ncbi.nlm.nih.gov/pubmed/34345306
http://dx.doi.org/10.3892/ol.2021.12942

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