Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice

BACKGROUND & AIMS: The lysosomal enzyme, cathepsin D (CTSD) has been implicated in the pathogenesis of non-alcoholic steatohepatitis (NASH), a disease characterised by hepatic steatosis and inflammation. We have previously demonstrated that specific inhibition of the extracellular CTSD leads to...

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Detalles Bibliográficos
Autores principales: Yadati, Tulasi, Houben, Tom, Bitorina, Albert, Oligschlaeger, Yvonne, Gijbels, Marion J., Mohren, Ronny, Lütjohann, Dieter, Khurana, Princy, Goyal, Sandeep, Kulkarni, Aditya, Theys, Jan, Cillero-Pastor, Berta, Shiri-Sverdlov, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323051/
https://www.ncbi.nlm.nih.gov/pubmed/34335574
http://dx.doi.org/10.3389/fimmu.2021.675535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323051/
https://www.ncbi.nlm.nih.gov/pubmed/34335574
http://dx.doi.org/10.3389/fimmu.2021.675535

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