Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice

Background: The K (ATP) channel plays a key role in glucose homeostasis by coupling metabolically generated changes in ATP to insulin secretion from pancreatic beta-cells.  Gain-of-function mutations in either the pore-forming (Kir6.2) or regulatory (SUR1) subunit of this channel are a common cause...

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Detalles Bibliográficos
Autores principales: Sachse, Gregor, Haythorne, Elizabeth, Proks, Peter, Stewart, Michelle, Cater, Heather, Ellard, Sian, Davies, Ben, Ashcroft, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323074/
https://www.ncbi.nlm.nih.gov/pubmed/34368464
http://dx.doi.org/10.12688/wellcomeopenres.15529.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323074/
https://www.ncbi.nlm.nih.gov/pubmed/34368464
http://dx.doi.org/10.12688/wellcomeopenres.15529.2

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